Distribution and Antibiotic Sensitivity Profile of Skin Infection Causing Pathogens in District Peshawar, Pakistan
Keywords:
Dermatophytes, Skin infection, Antibiotic sensitivity, Bacterial secies, Fungal speciesAbstract
OBJECTIVES
The study aimed to evaluate the distribution and antibiotic sensitivity profile of dermatophytes fungi and skin infection-causing bacterial pathogens in the district of Peshawar, Pakistan.
METHODOLOGY
A cross-sectional study was conducted from February 2022 to July 2022 in Microbiology Section, Complex Medical Laboratory Peshawar, Pakistan. A total of 100 skin-infected patients’ pus, nail, and skin scraping samples were processed for the isolation of fungal and bacterial pathogens.
RESULTS
Out of 100 skin-infected patient samples, the distribution of Escherichia coli was higher at 44.23%, followed by Staphylococcus aureus at 25%, Proteus species at 21.15%, Klebsiella spp. 5.76%, and Pseudomonas aeruginosa 3.84%, respectively. Among fungal pathogens, the distribution of Candida spp. was higher at 44.44%, followed by Aspergillus spp. 22.22%, Rhizopus spp. 16.16%, Mucor spp. 11.11%, Paecilomyces lilacinus 5.55%, respectively. The E. coli showed high resistance to amoxicillin 86.95%, S. aureus was high resistance to ciprofloxacin, levofloxacin 84.61%, Klebsiella spp. was found high resistance to amoxicillin and meropenem 100%, Proteus spp. has found high resistance to ciprofloxacin, amoxicillin 81.81%, and P. aeruginosa was highly resistant to doxycycline, aztreonam 100%. The candida spp. was found high resistance to nystatin at 87%, Aspergillus spp. were founded highly resistant to nystatin at 100%, Mucor spp. was high resistance to fluconazole, ketoconazole, and clotrimazole (100%), Rhizopus spp. was found resistant to itraconazole 100%, P. lilacinus was found highly resistant to itraconazole, nystatin 100%.
CONCLUSION
The study of antibiotic resistance pattern is suggested, which help the basis for modifications in skin infection therapy. A molecular study was also needed to identify the resistance gene among these pathogens and their immunogenicity.
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